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작성자미나 조회 4회 작성일 2021-04-15 09:30:45 댓글 0

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2019 Keynote Speaker Richard Knight - Prion Diseases, An Overview

Richard Knight, BA, BM BCh, FRCP(E), Chair, Management Committee, the UK CJD Support Network

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Hyperekplexia as the presenting symptom of Creutzfeldt-Jakob disease

We describe a patient with hyperekplexia as the initial presenting symptom in sporadic Creutzfeldt-Jakob disease (CJD). We also demonstrate the utility of the sensitive and highly specific new prion protein amplification assay, real-time quaking-induced conversion (RT-QUIC), which amplifies and detects misfolded β-sheet–rich conformers of the prion protein (PrPsc), in expediting a confident clinical diagnosis of CJD in an atypical case.

For more, see: http://cp.neurology.org/content/5/6/498.extract

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